Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators
Alessio Romerio, Francesco Peri, Front Immunol. (2020), 11:1210 Overview Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by Pathogen- and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers pro-inflammatory responses that belong to the repertoire of innate immune responses, consequently protecting against infectious challenges…